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KMID : 1007020080060020087
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Korean Soceity of Osteroporosis
2008 Volume.6 No. 2 p.87 ~ p.96
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Secondary Osteoporosis and Skeletal Related Event (SRE) in Non-Hodgkin’s Lymphoma Treated with High Dose Glucocorticoids
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Kim Yang-Soo
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Abstract
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Objectives: Glucocorticoids contribute to an increased prevalence of secondary osteoporosis and an increased incidence of fracture. This study was performed to determine risk of osteoporosis and skeletal related event associated with high dose steroid among non-Hodgkin\’s lymphoma (NHL) patients.
Methods: Data were taken retrospective medical database. From March 2004 to March 2008, newly diagnosed Non Hodgkin’s lymphoma patients treated with high dose glucocorticoids containing chemotherapy were examined bone mineral densitometry (BMD) studies before and end of chemotherapy courses. Skeletal related event were evaluated during all course of treatment.
Results: The prevalence of Skeletal related event defined as BMD -2.5 or less and 0.5 decline after treatment and development fracture is about 70%. Clinically meaningful and statistically significant factor associated with skeletal related event were age older than 60 yrs, baseline decline of BMD, 0.5 or more loss of femur and spine BMD after treatment. In multivariable analysis, the age older than 60 yrs and 0.5 or more loss of spine BMD are statistically significant risk factor.
Conclusion: Risk of osteoporosis and Skeletal related event is relatively high in NHL treated with high dose glucocorticoids containing chemotherapy. Preventive support and comprehensive evaluation for osteoporosis is warranted especially in elderly and patients who have history of previous bone loss.
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KEYWORD
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Glucocorticoid, Osteoporosis, Skeletal related event, Non-Hodgkin’s lymphoma
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